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Systematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction

Systematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction,Kevin A. Bybee,Toma

Systematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction   (Citations: 252)
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The transient left ventricular apical ballooning syndrome, also known as takotsubo cardiomyopathy, is characterized by transient wall-motion abnormalities involving the left ventricular apex and mid-ventricle in the absence of obstructive epicardial coronary disease. In this paper, we review case series that report on patients with the transient left ventricular apical ballooning syndrome to better characterize patients presenting with the syndrome. We identified 7 case series that reported on at least 5 con- secutive patients with the transient left ventricular apical balloon- ing syndrome. The syndrome more often affects postmenopausal women (82% to 100%) (mean age, 62 to 75 years). Patients commonly present with ST-segment elevation in the precordial leads, chest pain, relatively minor elevation of cardiac enzyme and biomarker levels, and transient apical systolic left ventricular dys- function despite the absence of obstructive epicardial coronary disease. An episode of emotional or physiologic stress frequently precedes presentation with the syndrome. The in-hospital mortal- ity rate seems to be low, as does the risk for recurrence.
Published in 2004.
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    • ...Tako-tsubo syndrome, however, is more common in females over 45 years, is often preceded by a psychological stress, and is associated with wall motion abnormalities mainly affecting the apical region [15]...

    Marcello Costantiniet al. Presumptive myocarditis with ST-Elevation myocardial infarction presen...

    • ...Neurogenic cardiomyopathy (NC) is a reversible segmental or global abnormality of cardiac function that may develop as a consequence of various inciting factors ranging from acute emotional distress to apoplectic intracranial processes [1]...

    Michael MoussouttasEdwinet al. CSF Catecholamine Profile in Subarachnoid Hemorrhage Patients with Neu...

    • ...• Takotsubo cardiomyopathy is a syndrome of transient left ventricular dysfunction seen predominantly in postmenopausal women following acute physical or emotional stress.• Neurocardiogenic injury from acute neurologic pathology can present with a spectrum of clinical findings including EKG changes, cardiac biomarker release, and transient left ventricular dysfunction (‘neurogenic stunned myocardium’) which may be indistinguishable from takotsubo cardiomyopathy.Novel Insights• Occurrence of neurogenic stunned myocardium in this patient with a history of takotsubo cardiomyopathy suggests that susceptibility to this condition is related to patient-specific factors rather than etiology, and neurologic conditions should be included as precipitants of takotsubo cardiomyopathy.• Significantly higher cardiac biomarker release and more prominent EKG changes on the second presentation suggest gradation based on degree of stress and there may be patients with milder forms of stress-related cardiac injury who do not develop the classic appearance of this cardiomyopathy.IntroductionThe initial Mayo clinic criteria for diagnosis of takotsubo cardiomyopathy published in 2004 required exclusion of pheochromocytoma, head injury, intracranial bleeding, and myocarditis [...

    Amit S. Dandeet al. Takotsubo Cardiomyopathy Followed by Neurogenic Stunned Myocardium in ...

    • ... Symptoms occur after emotional or physical stres...

    Helge Möllmannet al. Mechanisms of stress (Takotsubo) cardiomyopathy

    • ...TTC shares typical features of myocardial infarction but is not caused by obstructive coronary artery disease [1, 2]. TTC was primarily described in the Japanese population in the 1990s, but is now increasingly found in other parts of the world also...
    • ...Reported in-hospital mortality rates range from 0–8% [1]...
    • ...Heart failure medication such as ACE inhibitors, beta- blockers and diuretics are suggested because of the temporary LV dysfunction; aspirin is also recommended [1]...

    Daniela Primetshoferet al. Tako-Tsubo syndrome: an important differential diagnosis in patients w...

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