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Logical Knowledge Representation of Regulatory Relations in Biomedical Pathways

Logical Knowledge Representation of Regulatory Relations in Biomedical Pathways,10.1007/978-3-642-15020-3_17,Sine Zambach,Jens Ulrik Hansen

Logical Knowledge Representation of Regulatory Relations in Biomedical Pathways  
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Knowledge on regulatory relations, in for example regulatory pathways in biology, is used widely in experiment design by biomedical researchers and in systems biology. The knowledge has typically either been represented through simple graphs or through very expressive differential equation simulations of smaller sections of a pathway. As an alternative, in this work we suggest a knowledge representation of the most basic relations in regulatory processes regulates, positively regulates and negatively regulates in logics based on a semantic analysis. We discuss the usage of these relations in biology and in artificial intelligence for hypothesis development in drug discovery.
Published in 2010.
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