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Insulin and Renal Sodium Retention in Hypertension-Prone Men

Insulin and Renal Sodium Retention in Hypertension-Prone Men,Tomas Endre,Ingrid Mattiasson,Goran Berglund,U. Lennart Hulthdn

Insulin and Renal Sodium Retention in Hypertension-Prone Men   (Citations: 16)
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Insulin-stimulated peripheral glucose uptake and insulin-induced renal tubular sodium reabsorption were inves- tigated in normotensive men with a family history of hyper- tension (relatives, n=35) compared with age- and body mass index-matched normotensive men with no family history of hypertension (controls, n=23). The effect of insulin on the renin-aldosterone system was also studied. The euglycemic hyperinsulinemic clamp technique was used to measure pe- ripheral glucose uptake (insulin sensitivity index). Renal clear- ance of Cr-labeled EDTA, sodium, and lithium was used to calculate fractional excretion of sodium and fractional proxi- mal and distal tubular reabsorption of sodium before and during insulin infusion. The insulin sensitivity index was lower in relatives than in controls. Fractional excretion of sodium was reduced, and fractional proximal and distal tubular reab-
Published in 2010.
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