Academic
Publications
A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones

A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones,10.1038/310501a0,Nature,E. Carbone,H. D. Lux

A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones   (Citations: 195)
BibTex | RIS | RefWorks Download
Calcium channels in excitable membranes are essential for many cellular functions. Recent analyses of the burst-firing mode of some vertebrate neurones1-3 suggest that changes in their functional state are controlled by a Ca conductance that is largely inactivated at resting membrane potentials (-50 to -60 mV), but becomes activated following a conditioning hyperpolarization of the cell membrane. Here, using chick and rat sensory neurones, we present evidence for a new type of Ca channel with time- and voltage-dependent properties which is probably responsible for the inactivation behaviour of the Ca conductance. At membrane potentials between -50 and +10 mV, openings of this channel last 3-6 ms and tend to occur in rapid succession. Inactivation of this channel is indicated by prolonged and eventually complete closures brought about by long-lasting depolarizing voltage steps. This channel coexists in isolated membrane patches with the more common Ca channel4 which is less sensitive to changes in holding potential and shows a considerably shorter average life time and smaller currents.
Journal: Nature , vol. 310, no. 5977, pp. 501-502, 1984
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: