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Opening the gateway

Opening the gateway,10.1038/365486a0,Nature,A. Klug

Opening the gateway   (Citations: 11)
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Journal: Nature , vol. 365, no. 6446, pp. 486-487, 1993
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    • ...Both subsystems coordinate mutually their conformations through the flexible sugar rings [1, 2, 8, 9]. So, in modeling the transformations of the DNA double helix it is important to use the components for the description of internal conformational rearrangements and external transformation of macromolecule shape...
    • ...However, it is known [1, 2, 6, 8, 9, 13] that under rearrangements of DNA structure in the frame of the double helix the DNA structural elements move jointly along some conformational pathways...
    • ...Then, let us take into account that under such structural transformations as transitions between the B- and A-forms of the double helix, the nucleic bases in the pair displace together without significant mutual shifts and remain in the configuration of complementary pairs both in the initial and in the final helix forms [1, 2, 8, 9, 13]...
    • ...In fact, under the conformational transitions of B‐A type the mass center of DNA monomer link has the largest displacement in the plane which is orthogonal to the helix axis [1, 2, 8, 9, 13]...
    • ...Besides, it is also known [1, 2, 8, 9, 13], that under conformational transitions the base pairs displace transversely to the helix axis, along the axis 0X (Figure 1). Thus, for the component r it is expedient to express the displacement along the trajectory of the mass center motion: r → r ...
    • ...backbone. The displacements of base pair in the monomer link occur due to the conformation changes in both sugar rings [1, 2, 8, 9, 13]...

    S. N. Volkov. Modeling B–A Transformations of the DNA Double Helix

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