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Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly,10.1126/science.1060118,Science,Jun-ichi Nakayama,Judd C. Ri

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly   (Citations: 482)
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The assembly of higher order chromatin structures has been linked to the covalent modifications of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys9) is preferentially methylated by the Clr4 protein at heterochromatin-associated regions in fission yeast. Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys9 methylation in vivo. Localization of Swi6, a homolog of Drosophila HP1, to heterochomatic regions is dependent on H3 Lys9 methylation. Moreover, an H3-specific deacetylase Clr3 and a beta-propeller domain protein Rik1 are required for H3 Lys9 methylation by Clr4 and Swi6 localization. These data define a conserved pathway wherein sequential histone modifications establish a ``histone code'' essential for the epigenetic inheritance of heterochromatin assembly.
Journal: Science , vol. 292, no. 5514, pp. 110-113, 2001
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