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Assessment of Endothelial Function Using Arterial Pressure Signals

Assessment of Endothelial Function Using Arterial Pressure Signals,10.1007/s11265-009-0431-7,Journal of Signal Processing Systems,Hsien-Tsai Wu,Chun-H

Assessment of Endothelial Function Using Arterial Pressure Signals   (Citations: 5)
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Peripheral arterial tonometry (PAT) is a useful method to assess endothelial function. Analysis of pulse wave amplitude with PAT during reactive hyperemia can be used to study peripheral vascular endothelial function very well. We had injected a specific nitric oxide (NO) synthesize inhibitor intra-arterially into five adult male rats to verify the validation of our proposed photoplethysmograpy (PPG) system for endothelial function assessment. However, the reproducibility was not good for the system applied for measuring fingertip peripheral arteries. Therefore, an air-pressure sensing system with the high reproducibility was developed for peripheral vascular endothelial function assessment. This study showed that the vasodilatation index measured with air-pressure sensing system correlated very well with that measured using peripheral arterial tonometry. In addition, only few minutes are needed for conducting a self endothelial function assessment at home. And, early self-monitoring of cardiovascular dysfunction and arterial stiffness can be easily and effectively achieved.
Journal: Journal of Signal Processing Systems - JSPS , vol. 64, no. 2, pp. 223-232, 2011
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    • ...On the other hand, it has been demonstrated that data obtained through PPG are frequently affected by a variety of environmental and physiological factors, including temperature, motion, respiration, sympathetic activity, and more importantly, arteriolar blood flow in fingertip, and its autoregulation [11]–[13], thereby causing unstable pulse wave extraction and hampering the accuracy of arterial stiffness determination...
    • ...proposed a noninvasive and easily operable air pressure sensing system (APSS) for the radial artery [13]...
    • ...The analog signals were then digitized with an analog-to-digital converter (ADC) and stored in a computer for later analysis [13]...
    • ...In addition, the PPG system (PWV-DVP) [4] was first used for the measurement, followed by the utilization of APSS [13]...
    • ...Although the conventional technique of waveform contour analysis using PPG on the fingertip is a widely applicable noninvasive method for monitoring arterial stiffness [3], the autoregulatory function of arteriolar blood flow precludes the stability and accuracy of the signals for prolonged monitoring [13]...

    Hsien-Tsai Wuet al. Arterial Stiffness Using Radial Arterial Waveforms Measured at the Wri...

    • ...We have previously validated the application of an air pressure sensing system (APSS) [4], [5] on the wrist in evaluating endothelial function based on RH using a Dilatation index (DI) which shows an excellent reproducibility and also a significant correlation with the RH-PAT index among young healthy subjects...
    • ...One pressure cuff of the air pressure sensing system (APSS) was then put around the left arm, whereas the other cuff was applied on the left wrist [4], [5]...
    • ...The structure and principle of operation of APSS has previously been reported in our previous study�≥ [4], [5]...
    • ...1). The Dilatation Index (DI) [4] of the forearm blood vessel is defined as:...
    • ...In concert with the results of previous studies [3], [4], our finding (see Figure 1) showed that the value of DI decreases with advancing age...
    • ...The present study utilized the air pressure sensing system (APSS) that we previously proposed to record the signals of arterial pulsations from the wrist before and after application of pressure on the upper arm [4], [5]...

    Chun-Ho Leeet al. Multiscale entropy indicates vascular abnormalities in the aged

    • ...In order to find and analyze hidden dynamical structures of these signals, the proposed system in [5] is used to collect the time series...
    • ...Previous study [5] had already shown that a novel endothelial function assessment via air pressure sensing system...
    • ...The instrument in [5] was composed of a portable interception device and a vasodilatation index analysis software...
    • ... . ,xn}, where xi is the ith amplitude of arterial pressure signals collected by using the proposed system in [5] as shown in Figure 2. Figures 3 and 4 are represented as amplitude time series at baseline and hyperemia conditions, respectively...
    • ...We investigate these questions with databases [5] that include 25 ostensibly healthy subjects with subgroups of young (one females and nine males, average 24 years) and elderly (ten females and five males, average 51 years), a group of subjects (n = 15) with diabetes mellitus (DM) (6 females and 9 males, average 59 years)...

    Hsien-Tsai Wuet al. Linguistic analysis of the arterial pressure signals using frequency a...

    • ...In our recent study [6], for the radial arterial pressure...
    • ...obtaining, amplifying and filtering the captured arterial pressure signal [6]...
    • ...The MRl not normalization was measured at wrist by the air pressure sensing system [6]...
    • ...DVP signal measured at finger. In the recent study [6],...

    Hsien-Tsai Wuet al. Predicting arterial stiffness with the aid of ensemble empirical mode ...

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