Academic
Publications
Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney

Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney,10.1152/ajprenal.00145.2010,Ajp: Renal Physiology,I. Mimura,M. Nangaku,H. Nishi,

Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney   (Citations: 3)
BibTex | RIS | RefWorks Download
Journal: Ajp: Renal Physiology , vol. 299, no. 2, 2010
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ... The sequences of primers used for human and rat EPO and β-actin mRNA are shown in Table 1...

    Chih-Kang Chianget al. Indoxyl sulfate, a representative uremic toxin, suppresses erythropoie...

    • ...and nitrosative stress, thus preserving kidney functioning and reducing fibrotic changes [73]...
    • ...Upon fibrogenic stimulus, pancreatic stellate cells and renal interstitial cells also expressed higher Cygb level and, simultaneously, synthesised more collagen [73, 79]...
    • ...It is of note, however, that while Cygb revealed anti-fibrotic properties, its enforced overexpression was also linked to reduced deposition of collagen protein in fibrotic liver [72] and kidney [73]...
    • ...Also, in vitro data indicate that exogenous Cygb overexpression decreases collagen mRNA and protein in kidney cell lines [73] and collagen mRNA in lung and breast cancer cell lines [80]...
    • ...Interestingly, Cygb knock-down did not affect collagen expression in kidney cell lines [73]...
    • ...Cygb was upregulated in hypoxic liver, heart [27, 87], muscle [87], to a smaller extent in brain [25, 87] and, after cobalt chloride-induced chemical hypoxia, in kidney [73]...
    • ...Fibrosis/myofibroblasts-specific higher levels of Cygb have also been found in other research models in fibrotic liver [31, 108, 110, 111], kidney [73] and pancreas [26, 79]...
    • ...It is of note that Cygb upregulation frequently coincided with collagen upregulation [26, 73, 79]...
    • ...In the study conducted by Mimura et al. [73], Cygb overexpression in transgenic rats attenuated the effect of subtotal nephrectomy by decreasing loss of renal function, kidney fibrosis, collagen deposition, fibroblast activation, macrophages infiltration and oxidative and nitrosative stress...
    • ...Hypothetically, it may provide an antioxidant defence, since antioxidant treatment has anti-fibrotic properties [51, 109] and Cygb overexpression was demonstrated to reduce oxidative stress in fibrotic models [72, 73]...

    Urszula Oleksiewiczet al. Cytoglobin: biochemical, functional and clinical perspective of the ne...

Sort by: