A synthetic oscillatory network of transcriptional regulators

A synthetic oscillatory network of transcriptional regulators,Nature,M. Elowitz,S. Leibler

A synthetic oscillatory network of transcriptional regulators (Citations: 923)


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Journal: Nature , 2000

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- ...One of the key challenges facing synthetic biology today is the ability to engineer large-scale, multicellular systems with sophisticated yet predictable and robust behaviors. Previous work in synthetic biology has successfully implemented and characterized a variety of relatively small synthetic gene networks including oscillators ...
Miles Miller, et al. Modular Design of Artificial Tissue Homeostasis: Robust Control throug...
- ... So far, most applications that utilize inducible gene expression have relied on transcription factors controlled by small molecules, like AraC, LacI or TetR ...
Christiane Georgi, et al. Promoter Strength Driving TetR Determines the Regulatory Properties of...
- ..., ...
Lorenzo Pasotti, et al. Bottom-Up Engineering of Biological Systems through Standard Bricks: A...
- ......
Linh Huynh, et al. Automatic Design of Synthetic Gene Circuits through Mixed Integer Non-...
- ...
  
  A repressilator, the three-inhibitor ring oscillator, was first constructed as a synthetic circuit in Escherichia coli...
Alexandra Pokhilko, et al. The clock gene circuit in Arabidopsis includes a repressilator with ad...

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