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Prediction of protein-protein interaction sites using patch analysis 1 1 Edited by G. von Heijne

Prediction of protein-protein interaction sites using patch analysis 1 1 Edited by G. von Heijne,10.1006/jmbi.1997.1233,Journal of Molecular Biology,S

Prediction of protein-protein interaction sites using patch analysis 1 1 Edited by G. von Heijne   (Citations: 159)
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A method for defining and analysing a series of residue patches on the surface of protein structures is used to predict the location of protein-protein interaction sites. Each residue patch is analysed for six parameters; solvation potential, residue interface propensity, hydrophobicity, planarity, protrusion and accessible surface area. The method involves the calculation of a relative combined score that gives the probability of a surface patch forming protein-protein interactions. Predictions are made for the known structures of protomers from 28 homo-dimers, large protomers from 11 hetero-complexes, small protomers from 14 hetero-complexes, and antigens from six antibody-antigen complexes. The predictions are successful for 66% (39/59) of the structures and the remainder can usually be rationalized in terms of additional interaction sites.
Journal: Journal of Molecular Biology - J MOL BIOL , vol. 272, no. 1, pp. 133-143, 1997
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