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Ambient mass spectrometry: bringing MS into the “real world”

Ambient mass spectrometry: bringing MS into the “real world”,10.1007/s00216-010-3808-3,Analytical and Bioanalytical Chemistry,Rosana M. Alberici,Rosin

Ambient mass spectrometry: bringing MS into the “real world”   (Citations: 5)
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Mass spectrometry has recently undergone a second contemporary revolution with the introduction of a new group of desorption/ionization (DI) techniques known collectively as ambient mass spectrometry. Performed in an open atmosphere directly on samples in their natural environments or matrices, or by using auxiliary surfaces, ambient mass spectrometry (MS) has greatly simplified and increased the speed of MS analysis. Since its debut in 2004 there has been explosive growth in the applications and variants of ambient MS, and a very comprehensive set of techniques based on different desorption and ionization mechanisms is now available. Most types of molecules with a large range of masses and polarities can be ionized with great ease and simplicity with the outstanding combination of the speed, selectivity, and sensitivity of MS detection. This review describes and compares the basis of ionization and the concepts of the most promising ambient MS techniques known to date and illustrates, via typical analytical and bioanalytical applications, how ambient MS is helping to bring MS analysis deeper than ever into the “real world” open atmosphere environment—to wherever MS is needed. Figure Schematic of EASI
Journal: Analytical and Bioanalytical Chemistry - ANAL BIOANAL CHEM , vol. 398, no. 1, pp. 265-294, 2010
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    • ...EASI is, however, an ambient ionization technique [13] which requires no sample handling at all, providing the fastest MS analysis (a few seconds) of the fully undisturbed sample in the open atmosphere...

    K. C. Cardosoet al. TAG Profiles of Jatropha curcas L. Seed Oil by Easy Ambient Sonic-Spra...

    • ...Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) [25, 26 ]i s an ambient ionization technique [21] which allows the direct and fast MS analysis of samples in the open atmosphere with little or no sample preparation...
    • ...Ionization by EASI is soft, causing no or minimum fragmentation [21]...
    • ...In conclusion, we showed that the EASI(±)-MS technique, one of the simplest ambient mass spectrometry techniques [21], is able to determine the phosphatidylcholine and TAG profiles of livers with no preseparation steps and with very little sample preparation...

    Luciane C. Albericiet al. Distinct hepatic lipid profile of hypertriglyceridemic mice determined...

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