How possible is the detection of correlated mutations?

How possible is the detection of correlated mutations?,10.1007/s002140050398,Theoretical Chemistry Accounts,P. Tufféry,M. Durand,P. Darlu

How possible is the detection of correlated mutations?   (Citations: 3)
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.   The remarkable conservation of protein structure, compared to that of sequences, suggests that, in the course of evolution, residue substitutions which tend to destabilise a particular structure must be compensated by other substitutions that confer greater stability on that structure. Given the compactness of proteins, spatially close residues are expected to undergo the compensatory process. Surprisingly, approaches designed to detect such correlated changes have led, until now, only to limited success in detecting pairs of residues adjacent in the three-dimensional structures. We have undertaken, by simulating the evolution of DNA sequences including sites mutating in a correlated manner, to analyse whether such poor results can be attributed to the detection methods or if this failure could result from a compensatory process more complex than that implicitly underlying the different approaches. Present results show that only methods taking into account the phylogenetic reconstruction can lead to correct detection.
Journal: Theoretical Chemistry Accounts - THEOR CHEM ACC , vol. 101, no. 1, pp. 9-15, 1999
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