Academic
Publications
Chemo-enzymatic synthesis of chiral 2-substituted succinic acid derivatives

Chemo-enzymatic synthesis of chiral 2-substituted succinic acid derivatives,10.1016/S0957-4166(99)00330-4,Tetrahedron-asymmetry,Murray D. Bailey,Ted H

Chemo-enzymatic synthesis of chiral 2-substituted succinic acid derivatives   (Citations: 2)
BibTex | RIS | RefWorks Download
Prochiral discrimination by the biocatalyst Alcalase®, an enzyme preparation of subtilisin Carlsberg, was used to effect enantio- and regioselective monohydrolysis of a variety of (RS)-2-substituted succinate diesters to afford the corresponding half esters in modest to excellent enantiomeric excesses (>99%). Exploitation of malonate chemistry, as well as recycling of the unhydrolyzed isomer from the enantioselective hydrolysis, has resulted in a process which is both practical and economical.
Journal: Tetrahedron-asymmetry , vol. 10, no. 17, pp. 3285-3295, 1999
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: