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An improved synthesis of (1 R,3 S)-3-[( tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid

An improved synthesis of (1 R,3 S)-3-[( tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid,10.1016/j.tetasy.2010.04.049,Tetrahedron-asymmetry,Matthe

An improved synthesis of (1 R,3 S)-3-[( tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid  
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An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid from 3-aminobenzoic acid is described utilising milder and more selective conditions. Both a classical salt resolution and an enzymatic approach have been shown to give the desired compound in high selectivity.
Journal: Tetrahedron-asymmetry , vol. 21, no. 7, pp. 864-866, 2010
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