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Preliminary evaluation of pharmacological properties of some xanthone derivatives

Preliminary evaluation of pharmacological properties of some xanthone derivatives,10.1016/j.bmc.2008.12.031,Bioorganic & Medicinal Chemistry,Henryk Ma

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Preliminary evaluation of pharmacological properties of some xanthone derivatives   (Citations: 4)
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A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for α1- and β1-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.
Journal: Bioorganic & Medicinal Chemistry - BIOORGAN MED CHEM , vol. 17, no. 3, pp. 1345-1352, 2009
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