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Synthesis and anti-HIV activity of oleanolic acid derivatives

Synthesis and anti-HIV activity of oleanolic acid derivatives,10.1016/S0960-894X(01)00647-3,Bioorganic & Medicinal Chemistry Letters,Yong-Ming Zhu,Jin

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Synthesis and anti-HIV activity of oleanolic acid derivatives   (Citations: 12)
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Thirteen oleanolic acid derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Saturating the C12–C13 double bond and converting the C17-carboxyl group to an aminomethyl group led to compounds 13–15 and 19–20, respectively, which showed improved anti-HIV activity. Compound 15 was the most potent derivative with EC50=0.0039μg/mL and TI=3570.
Journal: Bioorganic & Medicinal Chemistry Letters - BIOORG MEDICINAL CHEM LETTER , vol. 11, no. 24, pp. 3115-3118, 2001
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