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Designed Helical Peptides Inhibit an Intramembrane Protease
Designed Helical Peptides Inhibit an Intramembrane Protease,10.1021/ja037131v,Journal of The American Chemical Society,Chittaranjan Das,Oksana Berezov
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Designed Helical Peptides Inhibit an Intramembrane Protease
(
Citations: 18
)
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Chittaranjan Das
,
Oksana Berezovska
,
Thekla S. Diehl
,
Cedric Genet
,
Ilya Buldyrev
,
Jui-Yi Tsai
,
Bradley T. Hyman
,
Michael S. Wolfe
Journal:
Journal of The American Chemical Society - J AM CHEM SOC
, vol. 125, no. 39, pp. 11794-11795, 2003
DOI:
10.1021/ja037131v
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)
Citation Context
(5)
...To establish whether PS1/g-secretase presence and/or interaction with the APP substrate are needed to change positioning of APP-CT relative to the membrane, we used the previously characterized helical peptide (HP) g-secretase inhibitor, which docks to the substrate-binding site on g-secretase and prevents binding of APP to the PS1/g-secretase [
34
]...
...To inhibit the interaction between APP and PS1/g-secretase, cells were treated for 24 hours with 100 nM helical peptide (a gift from Dr. M. Wolfe, BWH, Boston, MA), which was designed to mimic a portion of the APP transmembrane domain and competes with APP for binding to PS1/g-secretase [
34
]...
Kengo Uemura
,
et al.
Reciprocal relationship between APP positioning relative to the membra...
... Treatment with GSMs led to a robust change in γ-secretase conformation only in the presence of substrates or a small helical peptide (HP) docking site inhibito
...
Kengo Uemura
,
et al.
Substrate docking to γ-secretase allows access of γ-secretase modulato...
... identified a putative initial substrate-binding site located on PS1, adjacent to the active site, using labeled helical peptides that mimic the APP transmembrane domai
...
Yuan Tian
,
et al.
An APP inhibitory domain containing the Flemish mutation residue modul...
...It should be noted that peptides analogous of the APP-TM domain that are too short to span the plasma membrane have also been shown to inhibit γ-secretase activity [
27
]...
Paul M Gorman
,
et al.
Dimerization of the transmembrane domain of amyloid precursor proteins...
...A recent precedent is the inhibition of the transmembrane enzymec-secretase bya-helical peptides at a transmembrane site removed from the active site (
Das et al., 2003
)...
Sharon Mendel
,
et al.
Interaction of the transmembrane domain of lysis protein E from bacter...
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Citations
(18)
Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation
Kengo Uemura
,
Katherine C Farner
,
Navine Nasser-Ghodsi
,
Phill Jones
,
Oksana Berezovska
Journal:
Molecular Neurodegeneration - MOL NEURODEGENER
, vol. 6, no. 1, pp. 1-10, 2011
Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
Kengo Uemura
,
Katherine C. Farner
,
Tadafumi Hashimoto
,
Navine Nasser-Ghodsi
,
Michael S. Wolfe
,
Edward H. Koo
,
Bradley T. Hyman
,
Oksana Berezovska
Journal:
Nature Communications
, vol. 1, 2010
An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production
Yuan Tian
,
Bhramdeo Bassit
,
Deming Chau
,
Yue-Ming Li
Journal:
Nature Structural & Molecular Biology - NAT STRUCT MOL BIOL
, vol. 17, no. 2, pp. 151-158, 2010
Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity
(
Citations: 8
)
J. V. McCarthy
,
C. Twomey
,
P. Wujek
Journal:
Experientia
, vol. 66, no. 9, pp. 1534-1555, 2009
γ-Secretase in biology and medicine
(
Citations: 6
)
Michael S. Wolfe
Journal:
Seminars in Cell & Developmental Biology - SEMIN CELL DEV BIOL
, vol. 20, no. 2, pp. 219-224, 2009