Block ionomer complex micelles with cross-linked cores for drug delivery
Soft polymeric nanomaterials were synthesized by template-assisted method involving condensation of the poly(ethylene oxide)-b-polycarboxylate
anions by metal ions into core-shell block ionomer complex micelles followed by chemical cross-linking of the polyion chains
in the micelle cores. The resulting materials represent nanogels and are capable of swelling in a pH-dependent manner. The
structural determinants that guide the self-assembly of the initial micelle templates and the swelling behavior of the cross-linked
micelles include the block ionomer structure, the chemical nature of metal ions, the structure of the cross-links and the
degree of cross-linking. The application of these materials for loading and release of a drug, cisplatin, is evaluated. These
cross-linked block ionomer micelles have promise for delivery of pharmaceutical agents.