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A fatal case of venlafaxine overdose

A fatal case of venlafaxine overdose,10.1007/BF03160945,Journal of Medical Toxicology,George M. Bosse,Henry A. Spiller,Aaron M. Collins

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A fatal case of venlafaxine overdose (Citations: 4)


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Introduction Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects. Case Report A 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed significant QRS and QTC interval prolongation prior to his demise. Discussion A literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.

Journal: Journal of Medical Toxicology , vol. 4, no. 1, pp. 18-20, 2008

DOI: 10.1007/BF03160945

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- ...Venlafaxine is known to be more toxic in overdose than other SSRIs due to its pro-convulsant activity as well as cardiac sodium channel blocking capacity [15, 16]...
Agnes N. Chan, et al. A Comparison of Venlafaxine and SSRIs in Deliberate Self-poisoning

References (5)

Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants (Citations: 66)

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Published in 2003.

Seizures, Ventricular Tachycardia, and Rhabdomyolysis as a Result of Ingestion of Venlafaxine and Lamotrigine (Citations: 17)

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Journal: Annals of Emergency Medicine - ANN EMERG MED , vol. 30, no. 5, pp. 704-708, 1997

Massive Venlafaxine Overdose Resulted in a False Positive Abbott AxSYM ® Urine Immunoassay for Phencyclidine (Citations: 7)

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Journal: Clinical Toxicology - CLIN TOXICOL , vol. 41, no. 7, pp. 999-1002, 2003

Keywords (6)

A fatal case of venlafaxine overdose,10.1007/BF03160945,Journal of Medical Toxicology,George M. Bosse,Henry A. Spiller,Aaron M. Collins

Citation Context (1)

Agnes N. Chan, et al. A Comparison of Venlafaxine and SSRIs in Deliberate Self-poisoning

References (5)

Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants (Citations: 66)

Seizures, Ventricular Tachycardia, and Rhabdomyolysis as a Result of Ingestion of Venlafaxine and Lamotrigine (Citations: 17)

Massive Venlafaxine Overdose Resulted in a False Positive Abbott AxSYM ® Urine Immunoassay for Phencyclidine (Citations: 7)

Cardiovascular and neurological toxicity of venlafaxine (Citations: 21)

Isolated venlafaxine-induced serotonin syndrome (Citations: 17)

Citations (4)

Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions (Citations: 1)

A Comparison of Venlafaxine and SSRIs in Deliberate Self-poisoning (Citations: 1)

Electrocardiogram changes and arrhythmias in venlafaxine overdose (Citations: 5)

Drugs and pharmaceuticals: management of intoxication and antidotes (Citations: 1)


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