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Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?

Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?,10.1007/s13167-010-0031-4,The Epma Journal,Olga Golubnitschaj

Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?   (Citations: 2)
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Prediction and prevention of glaucoma. Neurodegenerative eye disease glaucoma is the second leading cause of blindness with estimated 67 million patients worldwide. Molecular pathomechanisms of glaucoma demonstrate both a considerable overlap with and remarkable particularities compared to other neurodegenerative disorders e.g. Alzheimer’s disease. Identification of pathology-specific biomarker-sets is essential to develop advanced diagnostic approaches and personalised patients’ treatment. Subcellular imaging and expression patterns in blood as the reliable platform for early/predictive glaucoma diagnosis. Following key pathways are affected in glaucoma pathology: stress response, apoptosis and DNA-repair, adhesion, blood-brain-barrier-breakdown, tissue remodelling, transcription regulation, multidrug resistance and energy metabolism.
Journal: The Epma Journal , vol. 1, no. 2, pp. 237-244, 2010
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