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CAPweb: a bioinformatics CGH array Analysis Platform

CAPweb: a bioinformatics CGH array Analysis Platform,10.1093/nar/gkl215,Nucleic Acids Research,Stéphane Liva,Philippe Hupé,Pierre Neuvial,Isabel Brito

CAPweb: a bioinformatics CGH array Analysis Platform   (Citations: 22)
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Assessing variations in DNA copy number is crucial for understanding constitutional or somatic diseases, particularly cancers. The recently devel- opedarray-CGH(comparativegenomichybridization) technology allows this to be investigated at the genomic level. We report the availability of a web tool for analysing array-CGH data. CAPweb (CGH array Analysis Platform on the Web) is intended as a user-friendly tool enabling biologists to completely analyseCGHarraysfromtherawdatatothevisualiza- tion and biological interpretation. The user typically performs the following bioinformatics steps of a CGH arrayprojectwithinCAPweb:thesecureuploadofthe results of CGH array image analysis and of the array annotation (genomic position of the probes); first level analysis of each array, including automatic nor- malization of the data (for correcting experimental biases), breakpoint detection and status assignment (gain, loss or normal); validation or deletion of the analysis based on a summary report and quality cri- teria; visualization and biological analysis of the genomic profiles and results through a user-friendly interface. CAPweb is accessible at http://bioinfo. curie.fr/CAPweb.
Journal: Nucleic Acids Research - NAR , vol. 34, no. Web-Server, pp. 477-481, 2006
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