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(8)
B Cell
Case Report
Combination Chemotherapy
Mortality Rate
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Lymph Node
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A multicentric, hyaline vascular variant of Castleman's disease associated with B cell lymphoma: a case report
A multicentric, hyaline vascular variant of Castleman's disease associated with B cell lymphoma: a case report,10.4076/1757-1626-2-8183,Cases Journal,
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A multicentric, hyaline vascular variant of Castleman's disease associated with B cell lymphoma: a case report
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Mehmet Ali Erkurt
,
Ismet Aydogdu
,
Irfan Kuku
,
Emin Kaya
,
Bulent Mizrak
INTRODUCTION: Three histological variants (hyaline vascular, plasma cell, and mixed) and two clinical types (localized and multicentric) of Castleman's disease have been described. The risk of progression to lymphoma is higher in multicentric Castleman's disease and is associated with poorer outcomes and higher mortality rate. Multicentric Castleman's disease often requires systemic therapy. Complete resection of the involved node in localized Castleman's disease is curative, with no reported recurrences. CASE PRESENTATION: We report a case of a 66-year-old female with systemic symptoms and bilateral cervical lymph nodes which were initially diagnosed as the hyaline vascular variant of Castleman's disease and two years later after the initial diagnosis she was confirmed to
B cell
lymphoma. Following the treatment with
radiation therapy
to the cervical area and
combination chemotherapy
complete response
was achieved. CONCLUSION: Although it has rarely been reported, the malignant potential of the Castleman's disease must be kept in mind.
Journal:
Cases Journal - Cases J
, vol. 2, no. 1, 2009
DOI:
10.4076/1757-1626-2-8183
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References
(7)
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