The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs

The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs,10.1186/1897-4287-3-2-59,Hereditary Cancer in Clinical Practice,Jan Lubiński,Tom

The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs   (Citations: 6)
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Jan Lubiński, Tomasz Huzarski, Grzegorz Kurzawski, Janina Suchy, Bartłomiej Masojć, Marek Mierzejewski, Marcin Lener, Wenancjusz Domagała, Maria Chosia, Urszula Teodorczyk, Krzysztof Mędrek, Tadeusz Dębniak
The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.
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    • ...The same mutation has been reported to be one of the possible lung cancer genes [8]...
    • ...Since common mutations in the NOD2/CARD15 gene have already been associated with an increased odds ratio of developing cancers of the bowel or breast, and with the increased incidence of malignancy in Crohn’s disease and an overall increase in malignancies at other sites including breast, lung, larynx and ovary [8], we reasoned that there may be common genetic factors associated with breast cancer patients who reported cases of lung cancer ...

    Marcin Radosław Leneret al. Prevalence of the NOD2 3020insC mutation in aggregations of breast and...

    • ...A second genetic factor that has been linked to breast cancer risk is NOD2 [8] which has also been associated with an increased risk of lung cancer and a suggestion that it is also associated with laryngeal cancer risk [9]...
    • ...In particular, the NOD2 3020insC polymorphism seems to be associated with an approximate 2-fold increased susceptibility to early-onset breast cancer and laryngeal cancer [8,9]...

    Ewa Jaworowskaet al. Association between early-onset breast and laryngeal cancers

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