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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery,10.1016/S0092-8674(00)80405-5,Cell,Sandeep Robert Datta,Henr

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery   (Citations: 2171)
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Growth factors can promote cell survival by activating the phosphatidylinositide-3′-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3′K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.
Journal: Cell , vol. 91, no. 2, pp. 231-241, 1997
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