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Exertion-Induced rhabdomyolysis with acute renal failure and disseminated intravascular coagulation in sickle cell trait

Exertion-Induced rhabdomyolysis with acute renal failure and disseminated intravascular coagulation in sickle cell trait,10.1016/0002-9343(77)90247-9,

Exertion-Induced rhabdomyolysis with acute renal failure and disseminated intravascular coagulation in sickle cell trait   (Citations: 14)
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Journal: American Journal of Medicine - AMER J MED , vol. 63, no. 2, pp. 313-317, 1977
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    • ... Rhabdomyolysis with acute kidney injury and disseminated intravascular coagulation has been reported after rigorous military training in a patient with sickle trait...

    Jon I Scheinman. Sickle cell disease and the kidney

    • ...Whether or not the up-regulation of thrombomodulin in the muscle sarcoplasm plays a role in the pathophysiology of the acute phase of rhabdomyolysis remains uncertain. One possibility is that thrombomodulin may act as an anticoagulant factor in the damaged skeletal muscle. Disseminated intravascular coagulation and pulmonary embolism due to an activated coagulation system are severe complications in the course of rhabdomyolysis [,...

    Jing Huet al. Characteristic Expression of Thrombomodulin in the Muscle Sarcoplasm i...

    • ...During metabolic acidosis, complete oxidative degradation of pentose was impaired, further reducing the supply of energy, and the NADPH necessary to stabilize the membranes was probably lacking [21, 26, 37, 41]...
    • ...Moreover, haemolytic anaemia is known to be a common trait of some metabolic disorders in which muscle is also involved as PFK and phosphoglycerate kinase deficiencies [19, 21, 36]...

    N. Bresolinet al. Muscle glucose-6-phosphate dehydrogenase deficiency

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