Academic
Publications
Guidelines for adults on self-medication for the treatment of acute diarrhoea

Guidelines for adults on self-medication for the treatment of acute diarrhoea,10.1046/j.1365-2036.2001.00993.x,Alimentary Pharmacology & Therapeutics,

Guidelines for adults on self-medication for the treatment of acute diarrhoea   (Citations: 16)
BibTex | RIS | RefWorks Download
Journal: Alimentary Pharmacology & Therapeutics - ALIMENT PHARMACOL THERAPEUT , vol. 15, no. 6, pp. 773-782, 2001
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...]. Some review papers on the treatment of acute diarrhea in adults suggest loperamide as a first-line agent [...

    Su-Ting T Liet al. Loperamide Therapy for Acute Diarrhea in Children: Systematic Review a...

    • ...This is most likely to occur when stool weight exceeds 1000 g per 24 hours [5]...

    Lawrence R. Schiller. Chronic diarrhea

    • ...Racecadotril, also called acetorphan, is an enkephalinase inhibitor, presented as a purely antisecretory therapy with advantages over loperamide (Table 1) (1‐14), in particular because it does not slow gut transit (15)...
    • ...In humans, racecadotril 100 mg three times a day had no significant effect on orocecal transit (sulfazalazine test) and excretion of colonic markers (15)...
    • ...The theoretical risk of bacterial proliferation with loperamide has been largely dispelled by clinical trials and large worldwide experience (93, 94)...
    • ...It has been studied in acute diarrhea, traveler’s diarrhea, and various forms of chronic diarrhea: it acts rapidly (within 2 hr) and significantly reduces diarrhea duration and number of unformed stools, when compared to placebo (16, 94)...
    • ...It is effective in combination with antibiotics (94)...
    • ...Because acute diarrhea resolves in most patients within two to three days (94, 103, 104), spontaneous resolution of diarrhea can confound differences in clinical outcome in comparative studies, especially if long pretreatment periods of diarrhea are allowed...
    • ...Numerous studies in acute nondysenteric diarrhea show that loperamide is more effective than these agents, particularly with respect to its onset of action (94)...
    • ...A benefit proposed for racecadotril over loperamide is less constipation and abdominal distension (5, 6, 15, 102, 110)...
    • ...In fact, they have flaws in their design, which are similar to those in comparative studies of loperamide and adsorbents, showing equal efficacy of the latter agents (94)...
    • ...Yet, the superior efficacy of loperamide compared to adsorbents is well-established today (16, 94)...

    S. Huijghebaertet al. REVIEW: Racecadotril Versus Loperamide: Antidiarrheal Research Revisit...

    • ...Nathan et al specify that adults should be encouraged to drink fluids and eat salt rich foods and Wingate et al state otherwise healthy adults do not require ORS and there is no evidence that the formulations relieve or shorten the duration of the diarrhoea illness [4, 12]...
    • ...The intestinal stasis is thought to enhance the tissue invasion of bacterial pathogens and there is evidence that using it prolongs fever in Shigellosis [4, 10, 12]...
    • ...The first is the empirical treatment of travellers’ diarrhoea which has demonstrated good response to antibiotic treatment in clinical trials since the 1980s and repeatedly done so in double-blind placebo-controlled trials even with a single dose of Ciprofloxacin reducing duration from 3-5 to <1-2 days [4, 5, 7, 10, 12]...
    • ...This is interesting when as many as 25% of travellers’ diarrhoea cases have been shown to be due to invasive pathogens including Salmonella and Campylobacter [4, 5, 7, 10, 12]...

    S Bourneet al. THE MANAGEMENT OF ACUTE DIARRHOEA IN A HEALTHY ADULT POPULATION DEPLOY...

Sort by: