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Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome

Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome

Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome   (Citations: 30)
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Journal: Alimentary Pharmacology & Therapeutics - ALIMENT PHARMACOL THERAPEUT , vol. 23, no. 11, pp. 1655-1665, 2006
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    • ...In fact we observe a nonsignificant trend of functional potency being the reverse of agonist affinity in all of the 4 agonists that we tested. So, taking the binding and functional results together, they indicate that it is unlikely that renzapride would show any significant selectivity in vivo. This is a relevant consideration because the efficacy of renzapride has been established in treating patients with cIBS [...

    Helen R. Irvinget al. Investigations into the Binding Affinities of Different Human 5HT4 Rec...

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