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Peripheral blood stem cell transplantation for POEMS syndrome

Peripheral blood stem cell transplantation for POEMS syndrome,10.1038/sj.bmt.1703670,Bone Marrow Transplantation,KS Peggs,S Paneesha,PD Kottaridis,RK

Peripheral blood stem cell transplantation for POEMS syndrome   (Citations: 24)
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In common with other plasma cell dyscrasias in which a small tumour burden is associated with severe clinical symptoms (notably systemic AL amyloidosis) the possible benefits of dose intensification are yet to be fully explored in POEMS syndrome. One important issue is whether the toxicity of the procedure is significantly increased in this group. We report two cases of POEMS syndrome with solitary asymptomatic bone lesions treated with high-dose melphalan (200 mg/m2) and peripheral blood stem cell (PBSC) rescue. In both cases there was minimal peri-transplant morbidity and a subsequent substantial and maintained improvement in the peripheral neuropathy.
Journal: Bone Marrow Transplantation - BONE MARROW TRANSPLANT , vol. 30, no. 6, pp. 401-404, 2002
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    • ...Recently, several reports have indicated the effectiveness of high-dose chemotherapy (HDC) with autologous stem cell rescue for POEMS syndrome [8-11]...
    • ...As the outcome of conventional chemotherapy such as melphalan plus prednisolone was disappointing [2], HDC with autologous stem cell rescue has been introduced, showing promising results [8-11]...

    Hiroshi Kojimaet al. Successful Treatment of a Patient with POEMS Syndrome by Tandem High-D...

    • ...Recently, some authors have reported that high-dose melphalan with autologous peripheral blood stem cell transplantation (auto-PBSCT) was effective for treating refractory CFS [12-15]...
    • ...pruritis 58 y F [13] P, E, M, S G-CSF only HDM 200 mg/m2 P, E, M, S Bacteremia 56 y M [14] P, O, E, M, S CY 1.5 g/m2 HDM 200 mg/m2 P, M, S...
    • ...lesion, FN 38 y F [14] P, O, E, M, S, edema ? HDM 200 mg/m2 O, M, edema Mucositis, FN 44 y F [15] P, O, S, M CY 60 mg/kg � 2 d + G-CSF 1. HDM 140 mg/m2, 2. HDM 140 mg/m2 P, O, S...
    • ...Recently, some authors have reported that high-dose chemotherapy with auto-PBSCT was effective for refractory CFS in a total of 9 cases (Table 2) [12-15]...
    • ...In these reports [12-15], polyneuropathy improved in 8 of 9 cases (89%), organomegaly in 4 of 6 cases (67%), endocrinopathy in 4 of 8 cases (50%), monoclonal gammopathy in 8 of 9 cases (89%), and skin changes in 7 of 9 cases (78%) (Table 2). Polyneuropathy, organomegaly, and skin changes associated with VEGF secreted from abnormal plasma cells were improved by auto-PBSCT in many cases...

    Jun Ozakiet al. Refractory Crow-Fukase Syndrome (POEMS Syndrome) Successfully Treated ...

    • ...Age at transplantation, y 51 (20-63) Time from symptoms to diagnosis, mos 24 (3-36) Time from diagnosis to PBSCT, mos 4 (2-149) Prior therapies, no. 3 (0-7) Immunoglobulin, no. IgA/no...
    • ...Age at transplantation, y 51 (20-63) Time from symptoms to diagnosis, mos 24 (3-36) Time from diagnosis to PBSCT, mos 4 (2-149) Prior therapies, no. 3 (0-7) Immunoglobulin, no. IgA/no...
    • ...Creatinine level, mg/dL 1.1 (0.6-1.9) M-spike, g/L 2 (0-9.4) Serum albumin level, g/L 37 (27-41) Urine protein, g/day 0.16 (0.04-1.2) Bone marrow plasma cells, % 4 (1-10) Bardwick features† 4.5 (2-5) Mayo features‡ 7 (3-9)...
    • ...Creatinine level, mg/dL 1.1 (0.6-1.9) M-spike, g/L 2 (0-9.4) Serum albumin level, g/L 37 (27-41) Urine protein, g/day 0.16 (0.04-1.2) Bone marrow plasma cells, % 4 (1-10) Bardwick features† 4.5 (2-5) Mayo features‡ 7 (3-9)...

    Angela Dispenzieriet al. Peripheral blood stem cell transplantation in 16 patients with POEMS s...

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