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Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn’s disease

Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn’s disease,10.1111/j.1365-2036.2009.04070.x,Alim

Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn’s disease   (Citations: 4)
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Journal: Alimentary Pharmacology & Therapeutics - ALIMENT PHARMACOL THERAPEUT , vol. 30, no. 6, pp. 621-633, 2009
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    • ...The results are expressed as means ± standard error of the mean [22] and statistical significance were performed by ANOVA with Bonferroni post hoc test...

    Amar Madiet al. Pseudomonas fluorescens alters epithelial permeability and translocate...

    • ...Despite this enormous concentration of commensal microbes, the mucosa remains intact and inflammation, erosions or ulcerations are not observed under physiological conditions. This is due to the nature of the mucosal barrier. Defensive mechanisms prohibit the invasion of bacteria and the mucosa-associated immune system remains quiescent. Only in cases where bacteria invade the mucosa is the immune system rapidly activated to prevent systemic translocation and sepsis. This activation is associated with an inflammatory response and apoptotic reactions (collateral damage) to defend against further invasion of bacteria. The mucosal barrier consists of a densely packed mucosal cell layer connected by tight junctions. The most important component of the barrier, however, is the mucus layer, which is the first line of defense. Within this compartment a high concentration of defensins are present, which are actively secreted into the mucus [...

    Wolfgang Stremmelet al. Phosphatidylcholine (Lecithin) and the Mucus Layer: Evidence of Therap...

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