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Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy

Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy,10.1016

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Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy   (Citations: 17)
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Journal: Cardiovascular Research - CARDIOVASC RES , vol. 54, no. 1, pp. 85-94, 2002
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    • ...The hypertrophic response to myocardial infarction was measured by relative quantification of ANF, h-MHC and a-actin mRNA transcripts using TaqMan real-time PCR [14]...

    Sarah Fernandes, et al. Autologous myoblast transplantation after myocardial infarction increa...

    • ...Dosage was based on previous studies [20,21]...
    • ...Four longitudinal incisions were made in the LV septum and inferoposterior wall of hearts included in the 3-day study, so that endocardial and epicardial surfaces could be pressed flat on glass plates, as previously described [20]...
    • ...The endocardial and epicardial borders of the LV and the infarcted area were traced and quantified using computed planimetry [20]...
    • ...LV end-diastolic pressure (LVEDP) and dP/dt were measured 7 days after MI, under isoflurane anesthesia using micromanometer (Millar Instruments) as described [20]...
    • ...Zymography was performed by previously described methods [20]...

    Thomas Thum, et al. Bone marrow molecular alterations after myocardial infarction: Impact ...

    • ... Similarly, in rats, long-term combined therapy of the ETA-receptor antagonist darusentan with ACE inhibition improved cardiac failure after extensive myocardial infarction more effectively than monotherap...

    Norberto Perico, et al. New therapeutics that antagonize endothelin: promises and frustrations

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