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Is kidney function altered by the duration of cardiopulmonary bypass?

Is kidney function altered by the duration of cardiopulmonary bypass?,10.1016/S0003-4975(02)04559-9,Annals of Thoracic Surgery,Joachim Boldt,Torsten B

Is kidney function altered by the duration of cardiopulmonary bypass?   (Citations: 44)
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BackgroundCardiopulmonary bypass (CPB) is considered responsible for kidney damage. By using sensitive markers of kidney damage we assessed whether the length of CPB influences kidney function.
Journal: Annals of Thoracic Surgery - ANN THORAC SURG , vol. 75, no. 3, pp. 906-912, 2003
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    • ...Despite the ongoing discussion on role of perfusion pressure, there is a convincing data to suggest that increased CPB duration has deleterious effects on kidney function and promotes injury [1,10,22]...
    • ...Unfortunately the majority of the studies that report on CPB duration did not include CPB hemodynamics, specifically CPB-MAP, in the analysis and none of the studies evaluate the change relative to pre-operative pressures (i.e. delta MAP) [1,22]...

    Hussein D Kanjiet al. Difference between pre-operative and cardiopulmonary bypass mean arter...

    • ...Cardiopulmonary bypass times in excess of 90 min are more likely to cause renal damage [27]...

    Fatin Sammouret al. Renal Function of Patients with a Failing Fontan Circuit Undergoing To...

    • ...Studies have demonstrated that patients with CPB times more than 90 min showed more pronounced kidney damage than patients with CPB times less than 70 min [6]...

    Raja S. Abou El-Ellaet al. Acute Renal Failure and Outcome of Children with Solitary Kidney Under...

    • ...Stratification of the groups The patients were divided into two groups using the criteria of Boldt et al. [12]...
    • ...In this study, 100 patients were evaluated up to the 2nd postoperative day with changes in renal tubular enzymes being reported, including beta N-acetylgalactosaminidase and glutathione transferases [12]...
    • ...Additionally, the longer CPB duration is associated to an increase in proinflammatory cytokines such as TNF-a, IL-1, IL-6 and endotoxins, which may explain tubular injury and the deterioration of the renal function [12,20]...

    Fábio Papa TANIGUCHIet al. Cardiopulmonary bypass time as a risk factor for acute renal failure

    • ...After reviewing the available literature, it was observed an incidence of 0.7% to 31% [2-14] of ARF after on-pump coronary artery bypass grafting and requirements of dialitic therapy of 0.9% to 4.9% [5,11,12]...
    • ...However, the most recognized complication following cardiac surgery is acute renal failure (ARF), which has been the cause of high mortality and morbidity [1-22]...
    • ...The increase of renal dysfunction has been related to a number of factors, with the most important being the use and the time of CPB, age, preoperative renal function, use of inotropic drugs, use of intraoperative furosemide, and associated comorbidities, such as diabetes, heart failure, and peripheral vascular disease, among others [2-14]...
    • ...In the literature values ranging from 0.7% to 31%, and 1.3% to 90%, respectively, were found [2-14]...
    • ...In scientific literature, many factors have been related to the increase of renal injury incidence and the most important ones are the CPB use and time [3-5,7,11,13]; age [3,5,7,11]; preoperative renal function [3-5,7-11,22]; use of inotropic drugs [11]; use of intraoperative furosemide [10], and comorbidities associated such as diabetes [5,7], heart failure [5.7,8], and peripheral vascular disease [8]...
    • ...In the present study, the CPB time was not the most important factor in the development of ARF, what is corroborated by other studies [3-5,7,11,13]...
    • ...Boldt et al. [13] concluded that a CPB time > 90 minutes was the most important risk factor for ARF with the hypoxic effects being account for the reduced blood perfusion, which leads to distress and death of proximal convoluted tubule cells...

    Carlos Dorsaet al. Risk factors for the development of acute renal failure following on-p...

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