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Keywords
(1)
Parkinson Disease
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D- -Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
D- -Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease,10.1172/JCI200318797,Journal of Clinical Investigati
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D- -Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
(
Citations: 44
)
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K. Tieu
Journal:
Journal of Clinical Investigation - J CLIN INVEST
, vol. 112, no. 6, pp. 892-901, 2003
DOI:
10.1172/JCI200318797
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The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
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www.jci.org
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Citation Context
(6)
...5-fold increase in whole brain
β-
OHB levels (
...
Mayumi L Prins
.
Cerebral metabolic adaptation and ketone metabolism after brain injury
...In humans the major ketone body is BHB, and its oxidation can be considered to have three major benefits: conversion of BHB to ACA in the mitochondria generates a reducing equivalent of NADH, which increases energy in this redox couple [30]; conversion of ACA to acetoacetyl-CoA generates succinate, a substrate for complex II, and allows for possible bypass of complex I inhibition [
31
]; and ketone bodies increase acetyl-CoA levels in the ...
...Preclinical evidence indicates that ketone bodies can provide neuroprotective effects, showing that BHB is neuroprotective in models of Parkinson's disease, AD, hypoxia, and ischemia [
31
,35-38]...
Lauren C Costantini
,
et al.
Hypometabolism as a therapeutic target in Alzheimer's disease
...Furthermore, ketone bodies have been described to increase oxidative stress [
41
]; thus, they are likely to contribute to PON1 oxidative inactivation...
Elena Thomàs-Moyà
,
et al.
Time-dependent modulation of rat serum paraoxonase 1 activity by fasti...
...In cultured neurons treated with pharmacologic agents that block complex I, addition of ketone bodies restores complex I function [
13
]...
...(page number not for citation purposes) respiration and ATP production [
13
,16]...
...They proposed that DHB infusion overcomes the Complex I blockage by MPTP through the generation of succinate as an oxidative substrate not through reduction ROS [
13
]...
Zhong Zhao
,
et al.
A ketogenic diet as a potential novel therapeutic intervention in amyo...
...Similar results have been found in mice treated with the mitochondrial toxin 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a wellaccepted model of Parkinson disease [
38
]...
...The authors show that D-BHB stimulates oxygen consumption and ATP production in isolated mitochondrial [
38
]...
Jana Mejía-Toiber
,
et al.
d -β-Hydroxybutyrate Prevents Glutamate-Mediated Lipoperoxidation and ...
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Citations
(44)
Clinical review: Ketones and brain injury
Hayden White
,
Balasubramanian Venkatesh
Journal:
Critical Care - CRIT CARE
, vol. 15, no. 2, pp. 1-10, 2011
Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives
(
Citations: 6
)
Qun Ren
,
Katinka Ruth
,
Linda Thöny-Meyer
,
Manfred Zinn
Journal:
Applied Microbiology and Biotechnology - APPL MICROBIOL BIOTECHNOL
, vol. 87, no. 1, pp. 41-52, 2010
Chronic in vitro ketosis is neuroprotective but not anti-convulsant
(
Citations: 4
)
Marina Samoilova
,
Michael Weisspapir
,
Peter Abdelmalik
,
Alexander A. Velumian
,
Peter L. Carlen
Journal:
Journal of Neurochemistry - J NEUROCHEM
, vol. 113, no. 4, pp. 826-835, 2010
Ketogenic diets: An historical antiepileptic therapy with promising potentialities for the aging brain
Marta Balietti
,
Tiziana Casoli
,
Giuseppina Di Stefano
,
Belinda Giorgetti
,
Giorgio Aicardi
,
Patrizia Fattoretti
Journal:
Ageing Research Reviews - AGEING RES REV
, vol. 9, no. 3, pp. 273-279, 2010
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
(
Citations: 34
)
Marwan Maalouf
,
Jong M. Rho
,
Mark P. Mattson
Journal:
Brain Research Reviews - BRAIN RES REV
, vol. 59, no. 2, pp. 293-315, 2009