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European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society Consensus Statement on Diabetic Ketoacidosis in Children and Adolescents

European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society Consensus Statement on Diabetic Ketoacidosis in Children and

European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society Consensus Statement on Diabetic Ketoacidosis in Children and Adolescents   (Citations: 65)
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D. B. Dunger, M. A. Sperling, C. L. Acerini, D. J. Bohn, D. Daneman, T. P. A. Danne, N. S. Glaser, R. Hanas, R. L. Hintz, L. L. Levitsky, M. O. Savage, R. C. Taskerhttp://academic.research.microsoft.com/io.ashx?type=5&id=28953743&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Pediatrics , vol. 113, no. 2, pp. e133-e140, 2004
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    • ...Diabetic ketoacidosis (DKA) in children is defined as hyperglycemia (serum glucose concentration >200–300 mg/ dL) in the presence of metabolic acidosis (blood pH<7.3 with serum bicarbonate level <15 mEq/L) and ketonemia (presence of ketones in blood) [2, 3]. As measurement of ketones in blood is not readily available, ketonuria is used as a marker of ketonemia...
    • ...Mild DKA is defined by venous pH between 7.2 and 7.3 or bicarbonate between 10 and15 mEq/L; moderate by pH between 7.1 and 7.2 or bicarbonate between 5 and 10 mEq/L; and severe by venous pH below 7.1 or bicarbonate below 5 mEq/L [2, 3]...
    • ...A diagnosis of DKA is made in presence of serum glucose concentration >200–300 mg/dL, blood pH<7.3, serum bicarbonate level <15 mEq/L and ketonemia [2, 3]. As rapid tests for detection of ketones in blood are usually not available, presence of ketones in the urine is looked for...

    Sindhu Sivanandanet al. Management of Diabetic Ketoacidosis

    • ...Although more common in type 1 diabetes mellitus, DKA is an established concern for type 2 diabetes [1, 2]. Diagnostic laboratory standards include hyperglycermia (>11 mmol/l or 200 mg/dl), a venous pH< 7.3, and/or bicarbonate <15 mmol/l [3]...
    • ...crine Society (ESPE/LWPES) [3] advocates the commencement of treatment...
    • ...Glucocorticoid therapy has been used for cerebral edema of various etiologies, but no result has been reported for the treatment of DKA-related cerebral edema [3, 7, 31]...

    Ha Son Nguyenet al. Lifesaving decompressive craniectomy for diffuse cerebral edema during...

    • ...Understanding which factors are associated with diabetic ketoacidosis at diagnosis and the relative importance of delayed diagnosis and treatment is, therefore, important. This potentially informs both our understanding of the disease as well as the development of patient, professional, and population based interventions to reduce the proportion of children presenting in diabetic ketoacidosis. Several individual factors from individual studies have been quoted in guidelines and consensus statements. ...

    Juliet A Usher-Smithet al. Factors associated with the presence of diabetic ketoacidosis at diagn...

    • ...Despite major advances in the care of diabetes, diabetic ketoacidosis remains a leading cause of morbidity, mortality, and hospital admission in children and adolescents with type 1 diabetes....

    Sasigarn A Bowden. Diabetic ketoacidosis at the onset of type 1 diabetes

    • ...Two years on, it seemed appropriate to assess the impact of the statement. First, however, the usefulness of a consensus statement bears consideration. In recent years, a growing number of consensus statements have been devised for various disorders....

    V. Pasterskiet al. Consequences of the Chicago consensus on disorders of sex development ...

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