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Fluidized Bed Adsorbent Systems for Extracorporeal Liver Support

Fluidized Bed Adsorbent Systems for Extracorporeal Liver Support,10.1111/j.1744-9987.2006.00357.x,Therapeutic Apheresis and Dialysis,Dieter Falkenhage

Fluidized Bed Adsorbent Systems for Extracorporeal Liver Support   (Citations: 9)
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Journal: Therapeutic Apheresis and Dialysis - THER APHER DIAL , vol. 10, no. 2, pp. 154-159, 2006
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    • ...This is essential for application of the cellulose microspheres for blood purification in the Microspheres-Based Detoxification System (MDS) (Falkenhagen et al. 2006; Weber et al. 2007)...
    • ...For this application, cellulose microspheres are functionalized by covalent binding of antibodies, antibody fragments or other bioactive molecules (Falkenhagen et al. 2006; Weber et al. 2010)...

    Katrin Thümmleret al. Preparation and characterization of cellulose microspheres

    • ...Detoxification System) [1-6], high specific micro adsorbent particles in the size of 1-25 micrometers circulate in an extracorporeal filtrate circle...

    M. Brandlet al. Particle Transfer and Detection in a Microspheres Based Detoxification...

    • ...TheMicrospheres BasedDetoxification System (MDS) [1-8] whichwedeveloped isanapheresis system consisting oftwocircuits whichareconnected through ahollow-fiber membranefilter...
    • ...Theprimary circuit corresponds tothe bloodcircuit ofconventional bloodpurification systems, whereas thesecondary circuit isaclosed loopdriven by high-velocity centrifugal- orother pumpsgenerating high flowrates (fig. 1). Microspheric adsorber particles circulate suspended inthesecondary filtrate circuit andgenerate a transmembrane filtrate flowwithhighly efficient adsorption characteristics...
    • ...Figure 1.Microsphere Detoxification System (MDS)...
    • ...Microspheres usedintheMDS canbedefined as microparticles withadiameter ofless than20ptm(range 1- 7ptm), comparable to thediameter of bloodcells...
    • ...Theoptical detection system forfluorescently labeled microparticles isplaced inthevenous blood line oftheMDS (fig. 1)...

    M. Brandlet al. Highly sensitive detection of labeled microparticles in blood

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