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CDKN2A-positive breast cancers in young women from Poland

CDKN2A-positive breast cancers in young women from Poland,10.1007/s10549-006-9382-x,Breast Cancer Research and Treatment,Tadeusz Dębniak,Cezary Cybuls

CDKN2A-positive breast cancers in young women from Poland   (Citations: 4)
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Purpose: To investigate the contribution of CDKN2A A148T common variant to early-onset breast cancer in Poland, and to establish the characteristic features of these cancers. Experimental design: We studied 3,069 women diagnosed with breast cancer under the age of 51 and 3,493 population controls. CDKN2A variant were detected using RFLP-PCR and confirmed by genomic sequencing. Clinical and pathological features of CDKN2A-positive cases and CDKN2A-negative cases were compared. Results: A148T variant was identified in 157 of 3,069 women with breast cancer (5.1%). Overall, the odds ratio for early-onset breast cancer, given a CDKN2A variant was 1.4 (95% CI 1.075–1.725; P = 0.012). Breast tumors in women with the CDKN2A variant were more commonly intraductal cancers (DCIS) with micro-invasion (14.8% vs. 8.5%; P = 0.035). Carriers and non-carriers were similar with respect to tumor size, laterality, multicentricity, nodal status, family history and estrogen-receptor status. Conclusion: The CDKN2A A148T variant seems to contribute to early-onset breast cancer in Poland. Breast tumors which arise in carriers of A148T variant appear to be similar to those of breast cancers in the population at large.
Journal: Breast Cancer Research and Treatment - BREAST CANCER RES TREAT , vol. 103, no. 3, pp. 355-359, 2007
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