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Decline in the AIDS and death rates in the EuroSIDA study: an observational study

Decline in the AIDS and death rates in the EuroSIDA study: an observational study,10.1016/S0140-6736(03)13802-0,Lancet,A. Mocroft,B. Ledergerber,C. Ka

Decline in the AIDS and death rates in the EuroSIDA study: an observational study   (Citations: 351)
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Journal: Lancet , vol. 362, no. 9377, pp. 22-29, 2003
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    • ...The advent of combination antiretroviral therapy (cART) has led to a dramatic increase in the life expectancy and quality of life for people living with HIV/AIDS (PLWHIV) (Mocroft et al, 2003; Palella et al, 1998) and has reduced the risk of vertical transmission to <1% when HIV-positive pregnant women receive cART according to current clinical practice guidelines (CPG), deliver by cesarean as indicated by CPG, and do not breastfeed (Loutfy et al, 2009; Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission, 2011)...

    Lise Huynhet al. Access to conception planning information and services for people livi...

    • ...To maximize its benefit, patients should begin antiretroviral therapy before their CD4 cell count falls below 200 cells/mm3 (Mocroft et al, 2003)...

    Abdoulaye Touréet al. First presentation for care of HIV-infected patients with low CD4 cell...

    • ...Antiretroviral (ARV) drugs have been effective in reducing morbidity and mortality worldwide among HIV-infected patients (Egger et al, 2002; Mocroft et al, 2003) but large numbers of patients are still experiencing treatment failure (Harries, Nyangulu, Hargreaves, Kaluwa, & Salaniponi, 2001)...

    S. Kunutsoret al. Improving adherence to antiretroviral therapy in sub-Saharan African H...

    • ...Although AIDS-related morbidity and mortality have significantly decreased since the introduction of effective antiretroviral therapy (ART) (Mocroft et al, 2003; Walensky et al, 2006), HIV-infected drug users may have less access to ART (Bogart, Kelly, Catz, & Sosman, 2000; Cofrancesco et al, 2008; Lucas, Cheever, Chaisson, & Moore, 2001; McGowan et al, 2011), be less adherent to ART (Arnsten et al, 2002; Hinkin et al, 2007; Mills et al, 2006), have poorer virologic control (Arnsten et al, 2002; Cofrancesco et al, 2008; Lucas et al, 2001), and ultimately have worse clinical outcomes than nondrug users (Hogg et al, 2002; Lima et al, 2009; Lucas, Gebo, Chaisson, & Moore, 2002; Qian et al, 2011; Wood et al, 2003)...

    Daniel A. Rasbachet al. Active cocaine use is associated with lack of HIV1 virologic suppressi...

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