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High expression of the Met receptor in prostate cancer metastasis to bone

High expression of the Met receptor in prostate cancer metastasis to bone,10.1016/S0090-4295(02)01954-4,Urology,Beatrice S Knudsen,Glenn A Gmyrek,Jenn

High expression of the Met receptor in prostate cancer metastasis to bone   (Citations: 31)
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ObjectivesExpression of the active Met receptor tyrosine kinase causes tumor metastasis in animal models. To begin to analyze whether Met expression might be related to the spread of prostate cancer cells, we investigated whether its expression correlates with prostate-specific antigen recurrence and whether its expression depends on the site of metastasis.
Journal: Urology , vol. 60, no. 6, pp. 1113-1117, 2002
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    • ...The Mainsail study, currently open and enrolling patients, will determine whether docetaxel combined with lenalidomide and prednisone has a superior survival to the standard docetaxel/ prednisone treatment [40]...

    Daniel P. Petrylak. Current Clinical Trials in Castrate-Resistant Prostate Cancer

    • ... Aberrant activation or overexpression of MET is a common event in prostate cancer (especially in castration-resistant bone metastases), and is associated with proliferation, invasion and angiogenesis...

    E S Antonarakiset al. Emerging therapeutic approaches in the management of metastatic castra...

    • ...We and others have reported that c-MET overexpression is positively associated with PCa progression [34,35]...

    Shumin Zhanget al. Vascular endothelial growth factor regulates myeloid cell leukemia-1 e...

    • ...High c-Met expression is observed in late stages and metastases of prostate cancer [8,10]...
    • ...Additionally, an inverse correlation between the expression of AR and c-Met has been observed in prostate epithelium and prostate cancer cell lines [8,10]...
    • ...C-Met inhibitors decrease proliferation of AR negative prostate cancer cells PC-3 and DU-145 are two frequently used human prostate cancer cell lines that have shown strong c-Met expression [7,8,10,26]...
    • ...Interestingly, C4-2 cells showed a greater response to PHA-665752 and PF-2341066 mediated inhibition than LNCaP cells, supporting the previous observation that androgen insensitive cells have higher expression of c-Met [7,8,10]...
    • ...The c-Met receptor tyrosine kinase had been shown to be involved in tumor proliferation and progression and overexpression of c-Met had been associated with advanced prostate cancer [6-10]...
    • ...This correlated with previous publications showing that androgen-insensitive cells possessed higher cellular levels of c-Met [7,8,10,32,33]...

    William H Tuet al. Efficacy of c-Met inhibitor for advanced prostate cancer

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