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Acetylsalicylic acid is compounding to antiplatelet effect of C-reactive protein

Acetylsalicylic acid is compounding to antiplatelet effect of C-reactive protein,10.1016/j.thromres.2006.01.004,Thrombosis Research,Magdalena Boncler,

Acetylsalicylic acid is compounding to antiplatelet effect of C-reactive protein   (Citations: 8)
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The contribution of inflammatory process to the modulation of platelet response to acetylsalicylic acid (ASA) remains obscure. In our study, we examined the in vitro effect of C-reactive protein (CRP) on the ASA-mediated inhibition of collagen-stimulated platelet reactivity. Influence of CRP on platelet responsiveness to ASA was analysed using classical turbidimetric aggregation and flow cytometry. When acting alone, both C-reactive protein and ASA inhibited collagen-dependent platelet aggregation and reduced the expressions of two platelet surface membrane activation markers: P-selectin and activated GPIIbIIIa complex. Compared to the effects observed for ASA alone, the simultaneous action of both agents lead to further reductions in platelet aggregation (by 56.7±1.0% vs. 14.9±0.6%, p<0.0001) and lowered the expressions of platelet surface membrane P-selectin (by 72.1±5.3% vs. 65.0±6.0%, p<0.01) and activated GPIIbIIIa (by 67.0±5.6% vs. 47.7±8.3%, p<0.01). In general, our findings showed for the first time the augmenting effect of native C-reactive protein in the antiplatelet action of acetylsalicylic acid. Thus, we conclude that the effectiveness of aspirin therapy may strongly depend upon the presence of native CRP in circulation.
Journal: Thrombosis Research - THROMB RES , vol. 119, no. 2, pp. 209-216, 2007
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    • ...IPI00022295.1 — — 37 14 3 — — — Platelet factor 4 variant precursor (pf4var1) (pf4alt) (cxcl411) [contains: platelet factor 4 variant(4-74); platelet factor 4 variant(5-74); platelet factor 4 variant (6-74)]...
    • ...IPI00022295.1 — — 37 14 3 — — — Platelet factor 4 variant precursor (pf4var1) (pf4alt) (cxcl411) [contains: platelet factor 4 variant(4-74); platelet factor 4 variant(5-74); platelet factor 4 variant (6-74)]...
    • ...IPI00022295.1 — — 37 14 3 — — — Platelet factor 4 variant precursor (pf4var1) (pf4alt) (cxcl411) [contains: platelet factor 4 variant(4-74); platelet factor 4 variant(5-74); platelet factor 4 variant (6-74)]...

    Judith A. Coppingeret al. Moderation of the platelet releasate response by aspirin

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