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Change in expression of miRlet7c, miR100, and miR218 from high grade localized prostate cancer to metastasis

Change in expression of miRlet7c, miR100, and miR218 from high grade localized prostate cancer to metastasis,10.1016/j.urolonc.2009.02.002,Urologic On

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Change in expression of miRlet7c, miR100, and miR218 from high grade localized prostate cancer to metastasis   (Citations: 17)
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ObjectiveMicroRNAs (miRNAs) are small noncoding regulatory RNAs (19–25 nucleotides) that play a major role in regulation of gene expression. They are responsible for the control of fundamental cellular processes that has been reported to be involved in human tumorigenesis. The characterization of miRNA profiles in human tumors is crucial for the understanding of carcinogenesis processes, finding of new tumor markers, and discovering of specific targets for the development of innovative therapies. The aim of this study is to find miRNAs involved in prostate cancer progression comparing the profile of miRNA expressed by localized high grade carcinoma and bone metastasis.
Journal: Urologic Oncology-seminars and Original Investigations , vol. 29, no. 3, pp. 265-269, 2011
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