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Characteristics of liver cirrhosis in Italy: results from a multicenter national study

Characteristics of liver cirrhosis in Italy: results from a multicenter national study,10.1016/j.dld.2003.07.007,Digestive and Liver Disease,T Stroffo

Characteristics of liver cirrhosis in Italy: results from a multicenter national study   (Citations: 14)
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Background. In 1992, the characteristics of liver cirrhosis in Italy were assessed in a cross-sectional study among 1829 cirrhosis patients attending 21 tertiary centres.Aim. To evaluate the characteristics of cirrhosis patients 9 years later.Patients. A total of 2185 consecutive cirrhosis patients were enrolled over a 6-month period in 79 hospitals located throughout Italy, randomly selected by means of systematic cluster sampling.Results. The main agent associated with cirrhosis was hepatitis C virus, which was found in 69.9% of the patients and was the only etiologic factor in 51.1% of the patients. Hepatitis B surface antigen was present in the serum of 13.0% of the cases (in 7.3%, it was the only etiologic factor). A history of alcohol abuse was found in 31.9% of the cases (12.4% without viral infection). Patients with hepatitis C virus-related cirrhosis were older (mean age of 64.4 years) and more likely to be female (male:female ratio of 0.7), compared to patients with other pathogenic factors. Virus-related cirrhosis was more likely to be observed in southern Italy, whereas alcohol-related cirrhosis was prevalent in the North.Conclusions. As found in the 1992 study, the results of the present study show that in Italy, liver cirrhosis is mainly associated with hepatitis C virus infection, reflecting the high prevalence of this infection in the general population.
Journal: Digestive and Liver Disease - DIG LIVER DIS , vol. 36, no. 1, pp. 56-60, 2004
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