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Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion

Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion,10.1677/ERC-08-0079,Endocrine-re

Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion   (Citations: 7)
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Journal: Endocrine-related Cancer - ENDOCR-RELATED CANCER , vol. 15, no. 3, pp. 787-799, 2008
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    • ...We previously described that ABI3BP expression is reduced in malignant thyroid samples, compared to normal thyroid and benign lesions [6-8]...
    • ...Furthermore, we demonstrated that ectopic expression of ABI3BP decreased tumor growth properties in vitro and in vivo, while induced senescence [8]...
    • ...Correlation of ABI3 and ABI3BP expression in thyroid tumors The level of ABI3 expression was correlated with the level of ABI3BP ,w hich was previously investigated in this set of samples [8]...
    • ...To this end, total RNA extracted from each clone was used for cDNA synthesis as described [8]...
    • ...Stably transfected clones for ARO and WRO were analyzed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay as described [8,16]...
    • ...in stably expressing ABI3 ARO and WRO cells and controls, as described [8]...
    • ...Western blot analysis was performed as described [8]...
    • ...Cell Migration from spheroids Because high migration capacity might be correlated with cell spreading and metastasis in vivo ,m igration from spheroids was assayed as previously described [8]...
    • ...The areas of spheroids were calculated as described [8]...
    • ...Since we previously investigated the level of ABI3BP in the aforementioned set of samples [8], we next correlated the expression of ABI3 with the expression observed for ABI3BP .W e found a medium positive correlation between reduced expression of ABI3 and ABI3BP (r = 0.346; p = 0.019; Figure 1B)...
    • ...We also provided evidence that ectopic expression of ABI3BP in ABI3BPdeficient carcinoma cell lines inhibited in vitro and in vivo cell growth [8]...
    • ...Based on our previous findings [6,8] and on the fact that ABI3BP was originally described as an ABI3-SH3-binding protein isolated by yeast two-hybrid technique [19], we investigated the expression of ABI3 in thyroid lesions...

    Flavia RM Latiniet al. ABI3 ectopic expression reduces in vitro and in vivo cell growth prope...

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