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Hemoglobin Is Expressed by Mesangial Cells and Reduces Oxidant Stress

Hemoglobin Is Expressed by Mesangial Cells and Reduces Oxidant Stress,10.1681/ASN.2007101085,Journal of The American Society of Nephrology,H. Nishi,R.

Hemoglobin Is Expressed by Mesangial Cells and Reduces Oxidant Stress   (Citations: 14)
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Journal: Journal of The American Society of Nephrology - J AMER SOC NEPHROL , vol. 19, no. 8, pp. 1500-1508, 2008
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    • ...Nishi et al. [20] demonstrated that Hb is expressed by mesangial cells in the kidney...

    Yangdong Heet al. Brain Alpha and Beta-Globin Expression after Intracerebral Hemorrhage

    • ...Indeed, the involvement of Hb in the protection of cells against nitrosative stress is a long-time recognized process [63], but Hb can also detoxify highly oxidizing radicals, yielding the ferric state as reported by Nishi et al. [64] in rat mesenglial cells...

    Josep A Calduch-Gineret al. Use of microarray technology to assess the time course of liver stress...

    • ...Microarray analysis and proteomics of perfused rat kidneys (to avoid blood contamination) detected the presence of α- and β-globin genes which were transiently up-regulated during chronic hypoxia (78)...
    • ...conditions (78). RT-PCR detected the presence of α- and βglobin mRNA but not the presence of the mRNA for AE1, a gene that is abundant in erythrocytes, in perfused isolated rat kidney glomeruli (78) suggesting that globin gene expression was not due to erythroid cell contamination...
    • ...conditions (78). RT-PCR detected the presence of α- and βglobin mRNA but not the presence of the mRNA for AE1, a gene that is abundant in erythrocytes, in perfused isolated rat kidney glomeruli (78) suggesting that globin gene expression was not due to erythroid cell contamination...
    • ...The restricted expression of globin genes to kidney glomeruli was confirmed by RT-PCR of different nephron compartments isolated by manual dissection or by laser capture microdissection (78)...
    • ...Immunoblotting studies using polyclonal antibodies to Hb detected its presence in lysates from glomeruli isolated form saline perfused kidneys (78)...
    • ...In situ hybridization using antisense RNA probes specific for rat α- and β-globin showed that these genes are expressed in the mesangial region of kidney glomeruli (78)...
    • ...This was supported by colocalization of staining for Hb with OX-7, a marker of mesangial cells (78) and by detection of α- and β-globin in primary cultures of rat mesangial cells (78)...
    • ...This was supported by colocalization of staining for Hb with OX-7, a marker of mesangial cells (78) and by detection of α- and β-globin in primary cultures of rat mesangial cells (78)...
    • ...<{[SECTION]}>664 Gomes et al. mesangial cells (78)...
    • ...In addition, overexpression of both the α- and β-globin genes in these cells led to reduction of reactive oxygen species and improved mesangial cell viability under hypoxic conditions (78) suggesting that the globin gene products may play a role in the scavenging of reactive oxygen species in rat kidney mesangial cells...
    • ...α and β Mesangial cells of kidney glomeruli Scavenging reactive oxygen species (78)...

    Ivone Gomeset al. Hemoglobin-derived Peptides as Novel Type of Bioactive Signaling Molec...

    • ...Originally detected in erythroid cells, Hb expression has been detected in eye, kidney, endometrium, activated macrophages and cultured alveolar epithelial cells [36-43]...

    Nobuhisa Ishikawaet al. Hemoglobin α and β are ubiquitous in the human lung, decline in idiopa...

    • ...and may also be related to cancer and infection. It is interesting that hemoglobin has been found in non-hematopoietic organs such as the kidney acting as an anti-oxidative defense agent ...

    Li Xieet al. Drug Discovery Using Chemical Systems Biology: Identification of the P...

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