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Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response

Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response,10.1182/blood-2003-07-2268,Blood,F.

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Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response   (Citations: 43)
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Journal: Blood , vol. 103, no. 7, pp. 2645-2647, 2004
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    • ...While the presence of antibodies against platelet glycoproteins has traditionally been considered to play a central role, several abnormalities involving the cellular mechanisms of immune modulation, such as the T helper 1(Th1) bias [2, 3], the decreased number or defective suppressive function of regulatory T cells [4, 5], and the platelet destruction by cytotoxicity T lymphocytes (CTL) [6, 7], have been described...
    • ...An increased Th1/Th2 ratio in the peripheral blood has been proposed to correlate with disease activity in ITP [2, 3], and CTL-mediated platelets lysis also plays important role in ITP [6, 7]. In addition, our recently unpublished study revealed elevated Th17 cells in ITP patients...
    • ...In accordance with previous reports [2, 3], our data demonstrated that the ITP is the manifestation of a type-1 polarized immune response, with elevated Th1 cells and Tcl cells...

    Xiaojuan Zhu, et al. Elevated Interleukin21 Correlated to Th17 and Th1 Cells in Patients wi...

    • ...Several studies indicate ITP patients were Th1 dominant with elevated IFN-γ or other th1 cytokines [30, 32]...

    Xiao-juan Zhu, et al. High-Dose Dexamethasone Inhibits BAFF Expression in Patients with Immu...

    • ...Some studies suggested a less prominent Th1 response [18] or even found a Th2 response in patients with chronic ITP [27], but most investigations described a higher Th1 response [20, 21, 23, 26]...
    • ...Most studies have found evidence supporting a Th1 polarization of the immune response in ITP in vitro [19, 20, 23, 29], whereas other studies have yielded inconsistent [2] or contradictory [27] results...

    Daoxin Ma, et al. Profile of Th17 cytokines (IL17, TGF-β, IL6) and Th1 cytokine (IFN-γ) ...

    • ...Redundant platelet self-antibodies were detected to interact on glycoprotein on platelet surface, such as GPIIb-IIIa or GPIa-IX [5, 6]. The dysregulation of platelet selfantibodies production and onset of ITP were speculated related to Th cell polarization in ITP patients because many studies reported a skewing Th1 cytokine profile in patients with active chronic ITP [7, 8] and a tendency to Th3 cytokine profile in patients with recent ...

    Jianhui Xu, et al. CD72 Polymorphism Associated with Child-Onset of Idiopathic Thrombocyt...

    • ...Recent investigations have substantiated a Th1 polarization of the immune response in ITP [10, 11]...

    Chengshan Guo, et al. Correction of Th1-dominant Cytokine Profiles by High-dose Dexamethason...

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