Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity
IntroductionThe clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to essential differentiated cell types, they may contribute to sex-specific differences in bone healing outcomes.
, vol. 45, no. 6, pp. 1065-1072, 2009