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Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity

Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity,10.1016/j.bone.2009.08.005,

Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity   (Citations: 3)
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IntroductionThe clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to essential differentiated cell types, they may contribute to sex-specific differences in bone healing outcomes.
Journal: Bone , vol. 45, no. 6, pp. 1065-1072, 2009
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    • ...Since female sex is thought to be one risk factor for delayed/non-union [12] and sex-speciWc diVerences in bone healing were recently demonstrated in a rat model [13], an additional group of 35 female, 12-weekold counterparts was also included in the study: F1 (female 1 mm, n = 23), F5 (female 5 mm, n = 12)...
    • ...Recently, sex-speciWc diVerences in bone healing were demonstrated in a 1.5-mm femoral osteotomy model in 12-month-old Sprague–Dawley rats, reXecting a clinically relevant elderly patient cohort [13]...
    • ...This compromised bone healing in female rats was related to a reduced number of MSCs in their bone marrow [13]...
    • ...In agreement with the aforementioned study of Strube et al. [13], we could demonstrate that female rats show a delay in callus bridging and an inferior mechanical competence of the regenerative tissue when compared to males...

    Manav Mehtaet al. A 5-mm femoral defect in female but not in male rats leads to a reprod...

    • ...In addition to perfusion, systemic metabolism, and age, previous animal and large clinical studies have identified female individuals to be at risk for impaired bone healing [2, 5, 11, 16, 22]...
    • ...We observed superior mechanical callus properties, a larger callus size, earlier bridging, and a higher mineralization and polar moment of inertia [Jz] in microcomputed tomography (lCT) in middle-aged male compared with female rats, both stabilized with rigid fixation [22]...
    • ...Recently published (maximum torque at failure [MTF], torsional stiffness [TS], qualitative radiographic score, Jz, cross-sectional area [CsAr]) results of the female aged groups of our first study [24] and of the semirigidly fixated aged male group of the second study [22] served as historical controls for comparison (all data published earlier are marked within the tables and figures)...
    • ...Superscript letters (a) [22] and (b) [24] indicate methods, in which historical controls of recently published parameters were used for statistical comparison...
    • ...Pseudarthroses were defined as a radiographic score of 3 (as described subsequently) at euthanasia and/or an interfragmentary gap that macroscopically contained only fibrotic tissue and showed low mechanical stability after removing the fixator [22]...
    • ...Whiskers indicate single SD. Superscript letters (a) [24] and (b) [22] indicate that the values have been recently published and were used as historical controls for statistical comparison...
    • ...Superscript letters (a) [24] and (b) [22] indicate that the values have been recently published and were used as historical controls for statistical comparison...
    • ... SD; * p values from two-way analysis of variance; post hoc tests and intergroup comparison for BV was performed (Fig. 7) because combined effects of gender and stability was significant regarding this parameter; BV = callus volume; Jz = polar moment of inertia; CsAr = callus cross-sectional area; TMD = callus tissue mineral density; BMD = callus mineral density; superscript letter (a) indicates that the values have been recently published ...
    • ...Whether this observation is somehow related to the findings of a previous study, in which a reduced mesenchymal stem cell quantity in the bone marrow of female animals was observed [22], will require further study...

    Manav Mehtaet al. Influence of Gender and Fixation Stability on Bone Defect Healing in M...

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