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Neuropsychological profile of prodromal Alzheimer's disease (Prd-AD) and their radiological correlates

Neuropsychological profile of prodromal Alzheimer's disease (Prd-AD) and their radiological correlates,10.1016/j.archger.2010.03.016,Archives of Geron

Neuropsychological profile of prodromal Alzheimer's disease (Prd-AD) and their radiological correlates   (Citations: 4)
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This study describes the cognitive profile of Prd-AD, the neuropsychological tests that may predict progression to dementia, and to study their brain structural correlates. We enrolled 24 stable amnesics who did not develop dementia after two years follow-up; 27 patients were considered as Prd-AD, in the initial visit, since they fulfilled NINCDS-ADRDA criteria after two years; 31 Alzheimer's disease (AD) patients and 27 controls (CTR). Structural magnetic resonance imaging (MRI), as well as a neuropsychological battery was performed at the initial visit. The key findings were: Prd-AD patients were characterized by prominent episodic memory dysfunction and minimal semantic memory and executive dysfunction. Semantic fluency test (Sem-Flu), delayed text memory test (Del-text-mem) and memory alteration test (M@T) (including both episodic and semantic memory), together with trail making test A (TMT-A), resulted significant predictors for dementia development in this group of amnesic patients. This optimal predictive model obtained an estimated accuracy of 53% after two years follow-up. M@T and semantic Sem-Flu test performance presented high correlation with decreased gray matter density in the left lateral temporal lobe. We conclude that Prd-AD is characterized by prominent episodic memory dysfunction and minimal semantic memory and executive dysfunction which are related with left medial, inferior and lateral temporal density loss, predominantly in the left side.
Journal: Archives of Gerontology and Geriatrics - ARCH GERONTOL GERIATR , vol. 52, no. 2, pp. 190-196, 2011
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    • ... Burk and Humes gave subjects either short (5 h) or long (15 h) training on the identification of words in noise, and found that the long but not the short training generalized from isolated words to fluent speech (...

    Sophia Vinogradovet al. Cognitive Training for Impaired Neural Systems in Neuropsychiatric Ill...

    • ... stable MCI (S-MCI) has been investigated, and episodic memory impairment seems to be a strong predictor of progression to dementia [2-4], although it is not specific as some patients will not develop AD. Impairment in other cognitive domains (executive function and language) has been described in Pr-AD, but there are discrepancies about which additional impaired area will most improve sensitivity and specificity for detecting Pr-AD [5-7]...
    • ...Semantic memory (measured usually with category fluency) and attention and executive functions (measured usually with TMT-A or Symbol Digit Modalities Test) have been described as predictors of clinical progression in several studies [5-7,13,19], mainly when combined with other episodic memory scores or general cognitive assessments...

    Ana Pozuetaet al. Detection of early Alzheimer's disease in MCI patients by the combinat...

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