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Effect of hypertension on the entry of I-labelled low density lipoprotein into the aortic intima in normal-fed rabbits

Effect of hypertension on the entry of I-labelled low density lipoprotein into the aortic intima in normal-fed rabbits,10.1016/0021-9150(76)90067-8,At

Effect of hypertension on the entry of I-labelled low density lipoprotein into the aortic intima in normal-fed rabbits   (Citations: 8)
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Journal: Atherosclerosis , vol. 24, no. 1-2, pp. 99-106, 1976
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    • ...)]. Such monolayers have permeabilities that are several orders of magnitude higher than endothelium in vivo, and interpretation of the data therefore requires great caution; transport pathways may well differ from those in vivo. Significant progress requires the development of methods for investigating transport-related signalling pathways in more physiological preparations, or for inducing more physiological transport properties in cultured endothelium.ConclusionThe view that uptake of plasma constituents by the arterial wall is a rate-limiting step in adult human disease is closely connected with the view that plasma cholesterol concentrations are important, since absolute uptake will depend on plasma concentrations as well as on wall permeability whether it occurs by diffusive or convective transport, or through vesicular pathways. Hence the evidence that elevated plasma cholesterol concentrations are a risk factor and the clinical success of lipid-lowering therapies support the ideas presented here. The same comments apply to elevated blood pressure since it, too, is known to increase uptake, by directly increasing convective transport, by stretching the wall or by inducing longer-term changes in wall properties [,,...

    Peter D. Weinberg. Rate-Limiting Steps in the Development of Atherosclerosis: The Respons...

    • ...Although endothelial permeability to lipoproteins is still not completely understood, an animal model study showed that a reduction in systemic blood pressure decreases permeability to LDL [15]...

    Ivanio Alves Pereiraet al. The role of inflammation, humoral and cell mediated autoimmunity in th...

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