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Parathyroid hormone–related peptide (PTHrP), parathyroid hormone/parathyroid hormone–related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws

Parathyroid hormone–related peptide (PTHrP), parathyroid hormone/parathyroid hormone–related peptide receptor 1 (PTHR1), and MSX1 protein are expresse

Parathyroid hormone–related peptide (PTHrP), parathyroid hormone/parathyroid hormone–related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws   (Citations: 1)
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    • ...Within the jaw, Msx-1 is expressed with the highest concentration in the PDL [9,11-13] and is coexpressed with RANKL on CNC-derived osteoblast and chondroblast progenitors [14-16]...
    • ...Because of the restriction of Msx-1 to the adult jaw and its co-expression with RANKL, a BP- and denusomab-related loss of RANKL and Msx-1 expression might explain the BP- and denosumab-related impairment of hard and soft tissue remodeling that is restricted to the jaw bone in ONJ [4,14]...

    Falk Wehrhanet al. Expression of Msx-1 is suppressed in bisphosphonate associated osteone...

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