Academic
Publications
SELDI-TOF MS profiling of serum for detection of nasopharyngeal carcinoma

SELDI-TOF MS profiling of serum for detection of nasopharyngeal carcinoma,10.1186/1756-9966-28-85,Journal of Experimental & Clinical Cancer Research,Y

SELDI-TOF MS profiling of serum for detection of nasopharyngeal carcinoma   (Citations: 2)
BibTex | RIS | RefWorks Download
BACKGROUND: No satisfactory biomarkers are currently available to screen for nasopharyngeal carcinoma (NPC). We have developed and evaluated surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) for detection and analysis of multiple proteins for distinguishing individuals with NPC from control individuals. METHODS: A preliminary learning set and a classification tree of spectra derived from 24 patients with NPC and a group of 24 noncancer controls were used to develop a proteomic model that discriminated cancer from noncancer effectively. Then, the validity of the classification tree was challenged with a blind test set, which included another 20 patients with NPC and 12 noncancer controls. RESULTS: A panel of 3 biomarkers ranging m/z 3–20 k was selected to establish Decision Tree model by BPS with sensitivity of 91.66% and specificity of 95.83%. The ability to detect NPC patients was evaluated, a sensitivity of 95.0% and specificity of 83.33% were validated in blind testing set. CONCLUSION: This high-flux proteomic classification system will provide a highly accurate and innovative approach for the detection/diagnosis of NPC.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: