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The signals of FGFs on the neurogenesis of embryonic stem cells

The signals of FGFs on the neurogenesis of embryonic stem cells,10.1186/1423-0127-17-33,Journal of Biomedical Science,Ching-Wen Chen,Chin-San Liu,Ing-

The signals of FGFs on the neurogenesis of embryonic stem cells   (Citations: 1)
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BACKGROUND: Neural induction is a complex process and the detailed mechanism of FGF-induced neurogenesis remains unclear. METHODS: By using a serum-free neural induction method, we showed that FGF1 dose-dependently promoted the induction of Sox1/N-cadherin/nestin triple positive cells, which represent primitive neuroblasts, from mouse embryonic stem (ES) cells. RESULTS: We demonstrated that FGF1, FGF2, and FGF4, but not FGF8b, enhanced this neurogenesis. Especially, FGF-enhanced neurogenesis is not mediated through the rescue of the apoptosis or the enhancement of the proliferation of Sox1+ cells. We further indicated that the inactivation of c-Jun N-terminal kinase-1 (JNK-1) and extracellular signal-related kinase-2 (ERK-2), but not p38 mitogen-activated protein kinase (MAPK), inhibited the neural formation through the inhibition of ES differentiation, but not through the formation of endomesodermal cells. CONCLUSIONS: These lines of evidence delineated the roles of FGF downstream signals in the early neural differentiation of ES cells.
Journal: Journal of Biomedical Science - J BIOMED SCI , vol. 17, no. 1, pp. 33-11, 2010
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