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Effect of procalcitonin-based guidelines compared with standard guidelines on antibiotic use in lower respiratory tract infections: the randomized-controlled multicenter ProHOSP trial

Effect of procalcitonin-based guidelines compared with standard guidelines on antibiotic use in lower respiratory tract infections: the randomized-con

Effect of procalcitonin-based guidelines compared with standard guidelines on antibiotic use in lower respiratory tract infections: the randomized-controlled multicenter ProHOSP trial   (Citations: 3)
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P Schuetz, M Christ-Crain, R Thomann, C Falconnier, M Wolbers, I Widmer, S Neidet, C Blum, T Fricker, U Schild, K Regez, R Schoenenbergerhttp://academic.research.microsoft.com/io.ashx?type=5&id=30454788&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Critical Care - CRIT CARE , vol. 13, no. Suppl 1, pp. P386-1, 2009
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    • ...Several biomarkers have been related to disease severity and outcome in LRTI and sepsis, including levels of the cardiac hormone atrial-natriuretic peptide (ANP) [13-17], the stress- and volume-dependent antidiuretic hormone (ADH, vasopressin) [21-25], the endothelium derived hormones endothelin-1 (ET-1) [11,18-20] and adrenomedullin (ADM) [8-12], and procalcitonin (PCT) a specific marker of bacterial infections [26-35]...
    • ...We therefore validated the usefulness of five previously reported prohormones for predicting serious complications in patients with CAP and other LRTI enrolled in the multicenter ProHOSP study [31,34]...
    • ...Study sample We measured biomarker levels in all patients with LRTIs enrolled in the multicenter ProHOSP study [31]...
    • ...Outcomes were assessed during hospital stay at days 3, 5, 7, at hospital discharge, and by structured phone interviews after 30 days by blinded medical students and adjudicated by an independent data-monitoring committee [31,34]...
    • ...Previous studies have demonstrated the clinical and scientific impact of the biomarker PCT on the antibiotic management of LRTI [26-32] but up to now, no study has investigated the clinical utility of a prognostic biomarker on the management of patients with LRTI...

    Philipp Schuetzet al. Prohormones for prediction of adverse medical outcome in community-acq...

    • ...To better understand perceptions of physicians, nurses, patients and relatives about the need for inpatient management of different types and severities of LRTIs, we conducted a prosp ective survey in patients enrolled in the multi-center ProHOSP trial [17,18] about the perceived necessity for inpatient management and necessary length of hospital stay...
    • ...Study Participants Data for this study were collected from patients enrolled in the multicenter ProHOSP study during the first winter season (between October 2006 until June 2007) who were able and willing to participate[17,18]...
    • ...A detailed description of the ProHOSP study and baseline characteristics of the participating hospitals has been published previously [17,18]...
    • ...Baseline characteristics This study includes 566 inpatients with LRTIs out of a total of 729 patients enrolled in the first winter season of the ProHOSP study [17,18]...
    • ...In some patients with immediate adverse outcomes and severest medical condition the completion of the questionnaire was not possible, thus the rate of adverse outcomes is lower as compared to original study population [17]...

    Claudia Baehniet al. Which patients with lower respiratory tract infections need inpatient ...

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